| Data | Ora | Casa | Trasferta | Fase | TV | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
V | 2022-02-28 | 02:00 | Cruz Azul |  | 1-2 |  | Santos Laguna | G7 | ||||
V | 2022-03-03 | 04:00 | Santos Laguna | | 3-2 |  | Pumas | G8 | ||||
V | 2022-03-14 | 02:00 | Santos Laguna | | 4-0 |  | Club Tijuana | G10 | ||||
V | 2022-04-04 | 02:00 | Santos Laguna | | 3-1 |  | Pachuca | G12 | ||||
V | 2022-05-01 | 23:00 | Atlético San Luis |  | 1-3 | | Santos Laguna | G17 | ||||
