| Total | 624 | 239 | (38%) | 221 | (35%) | 164 | (26%) |
| Casa | 312 | 165 | (53%) | 98 | (31%) | 49 | (16%) |
| Trasferta | 312 | 74 | (24%) | 123 | (39%) | 115 | (37%) |
V | 2022-05-06 | Lecce |  | 1-0 |  | Pordenone Calcio | G38 | ||
S | 2022-04-30 | Vicenza |  | 2-1 | | Lecce | G37 | ||
V | 2022-04-25 | Lecce | | 2-0 |  | Pisa | G36 | ||
S | 2022-04-18 | Reggina |  | 1-0 | | Lecce | G35 | ||
V | 2022-04-09 | Lecce | | 1-0 |  | SPAL 2013 | G34 | ||
V | 2022-04-05 | Ternana |  | 1-4 | | Lecce | G33 | ||
V | 2022-04-02 | Lecce | | 1-0 |  | Frosinone | G32 | ||
P | 2022-03-19 | Parma |  | 0-0 | | Lecce | G31 | ||
P | 2022-03-15 | Cosenza |  | 2-2 | | Lecce | G30 | ||
P | 2022-03-12 | Lecce | | 1-1 |  | Brescia | G29 | ||
P | 2022-03-06 | Perugia |  | 1-1 | | Lecce | G28 | ||
V | 2022-03-02 | Lecce | | 3-1 |  | Ascoli | G27 | ||
V | 2022-02-27 | Monza |  | 0-1 | | Lecce | G26 | ||
S | 2022-02-23 | Lecce | | 1-2 |  | Cittadella | G25 | ||
V | 2022-02-20 | Lecce | | 3-0 |  | Crotone | G24 | ||
P | 2022-02-16 | Alessandria |  | 1-1 | | Lecce | G23 | ||
P | 2022-02-13 | Lecce | | 1-1 |  | Benevento | G22 | ||
P | 2022-02-05 | Como 1907 |  | 1-1 | | Lecce | G21 | ||
V | 2022-01-26 | Lecce | | 2-1 | | Vicenza | G18 | ||
V | 2022-01-23 | Lecce | | 2-1 |  | Cremonese | G20 |
